PSMA-specific targeting module TMpPSMA

{
  "id": "MLC-T-ONC-016281",
  "term": "PSMA-specific targeting module TMpPSMA",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of soluble adapter molecules consisting of an antigen-binding moiety targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), linked to a peptide motif recognizable by UniCAR02-T, that may be used to activate UniCAR02-T. Upon administration of PSMA-specific targeting module (TM) TMpPSMA, and upon co-administration of UniCAR02-T, the antigen-binding moiety of TMpPSMA targets and binds to cancer cells expressing PSMA, and the binding domain of UniCAR02-T binds to the nuclear antigen motif of TMpPSMA. This activates UniCAR02-T, and induces selective toxicity in and causes lysis of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.",
  "synonyms": [
    "TMpPSMA",
    "PSMA peptide target module TMpPSMA",
    "PSMA-specific TM TMpPSMA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/psma-specific-targeting-module-tmppsma/"
}