anti-PSMA/CD3 bispecific antibody REGN4336

{
  "id": "MLC-T-ONC-011058",
  "term": "anti-PSMA/CD3 bispecific antibody REGN4336",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody that targets both the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T lymphocytes, with potential immunostimulatory and antineoplastic activities. Upon administration of anti-PSMA/CD3 bispecific antibody REGN4336, this bispecific antibody binds to both CD3 on cytotoxic T lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.",
  "synonyms": [
    "PSMA X CD3 bispecific antibody REGN4336"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-psma-cd3-bispecific-antibody-regn4336/"
}