anti-PSMA/anti-CD3 T-cell engaging bispecific antibody TNB-585

{
  "id": "MLC-T-ONC-011054",
  "term": "anti-PSMA/anti-CD3 T-cell engaging bispecific antibody TNB-585",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell engaging bispecific antibody directed against the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-PSMA/anti-CD3 T-cell engaging bispecific antibody TNB-585 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.",
  "synonyms": [
    "PSMAxCD3 T-cell engaging bispecific antibody TNB-585"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-psma-anti-cd3-t-cell-engaging-bispecific-antibody-tnb-585/"
}