anti-CD3/anti-BCMA bispecific antibody TQB2934

{
  "id": "MLC-T-ONC-010375",
  "term": "anti-CD3/anti-BCMA bispecific antibody TQB2934",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell engaging, human, bispecific, immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD3/anti-BCMA bispecific antibody TQB2934 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival.",
  "synonyms": [
    "bispecific antibody TQB2934",
    "anti-CD3/BCMA bispecific antibody TQB2934",
    "anti-BCMA/anti-CD3 bispecific antibody TQB2934",
    "anti-CD3 x BCMA double-specific antibody TQB2934",
    "anti-CD3/anti-BCMA T-cell engaging bispecific antibody TQB2934"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-anti-bcma-bispecific-antibody-tqb2934/"
}