anti-BCMA/anti-CD3 bispecific antibody EMB-06

{
  "id": "MLC-T-ONC-010163",
  "term": "anti-BCMA/anti-CD3 bispecific antibody EMB-06",
  "field": "Oncology and biomedicine",
  "definition": "A tetravalent, bispecific antibody directed against both the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-BCMA/anti-CD3 bispecific antibody EMB-06 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a receptor for a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. In EMB-06, the two antigen-binding fragments (Fabs) are fused directly in a crisscross orientation resulting in four active and independent antigen binding sites.",
  "synonyms": [
    "anti-BCMA/CD3 bispecific antibody EMB-06",
    "BCMAxCD3 bispecific antibody EMB-06",
    "anti-BCMA/anti-CD3 FIT-Ig bispecific antibody EMB-06",
    "Fabs-in-tandem immunoglobulin bispecific antibody EMB-06"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-bcma-anti-cd3-bispecific-antibody-emb-06/"
}