anti-BCMA/anti-CD3 T-cell engaging bispecific antibody ABBV-383

{
  "id": "MLC-T-ONC-010166",
  "term": "anti-BCMA/anti-CD3 T-cell engaging bispecific antibody ABBV-383",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell engaging, human, bispecific, immunoglobulin G4 (IgG4) monoclonal antibody (T-BsAb) directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and CD3 antigen found on T lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-BCMA/anti-CD3 T-cell engaging bispecific antibody ABBV-383 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival. Binding to low-activating CD3 preferentially activates effector over regulatory T cells and stimulates minimum cytokine release.",
  "synonyms": [
    "anti-BCMA x aCD3 T-cell-engaging bispecific antibody TNB-383B",
    "BCMA x CD3 T-cell-engaging bispecifc antibody ABBV-383",
    "anti-BCMA x aCD3 T-BsAb TNB-383B",
    "anti-alpha BCMA/anti-alpha CD3 T-cell engaging bispecific antibody TNB-383B",
    "anti-BCMA x aCD3 T-cell engaging bispecific antibody TNB-383B",
    "BCMA x CD3 T-cell engaging bispecific antibody ABBV-383"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-bcma-anti-cd3-t-cell-engaging-bispecific-antibody-abbv-383/"
}