anti-BCMA/GPRC5D/CD3 trispecific antibody SIM0500

{
  "id": "MLC-T-ONC-010172",
  "term": "anti-BCMA/GPRC5D/CD3 trispecific antibody SIM0500",
  "field": "Oncology and biomedicine",
  "definition": "A humanized T-cell engager and trispecific antibody targeting the two tumor-associated antigens (TAAs) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and human G-protein coupled receptor family C group 5 member D (GPRC5D), and the T-cell surface antigen CD3, with potential immunomodulating and antineoplastic activities. Upon administration, anti-BCMA/GPRC5D/CD3 trispecific antibody SIM0500 simultaneously targets and binds to BCMA and GPRC5D expressed on tumor cells, and CD3 expressed on T cells. The resulting cross-linkage activates and redirects CTLs to GPRC5D- and BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival. GPRC5D is overexpressed on certain tumors, including multiple myeloma, while minimally expressed on normal, healthy cells, and plays a key role in tumor cell proliferation.",
  "synonyms": [
    "anti-GPRC5D/anti-BCMA/anti-CD3 trispecific antibody SIM0500",
    "GPRC5D-BCMA-CD3 trispecific antibody SIM0500",
    "GPRC5DxBCMAxCD3 trispecific antibody SIM0500"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-bcma-gprc5d-cd3-trispecific-antibody-sim0500/"
}