anti-CD3/anti-5T4 bispecific antibody GEN1044

{
  "id": "MLC-T-ONC-010374",
  "term": "anti-CD3/anti-5T4 bispecific antibody GEN1044",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant immunoglobulin G1 (IgG1) bispecific antibody targeting both the human T-cell surface antigen CD3 and oncofetal antigen 5T4, with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD3/anti-5T4 bispecific antibody GEN1044 simultaneously targets and binds to CD3 expressed on T cells and 5T4 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness.",
  "synonyms": [
    "anti-CD3/5T4 bispecific antibody GEN1044",
    "duobody-CD3x5T4"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd3-anti-5t4-bispecific-antibody-gen1044/"
}