anti-5T4/MMAE antibody-drug conjugate XB010

{
  "id": "MLC-T-ONC-010110",
  "term": "anti-5T4/MMAE antibody-drug conjugate XB010",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the oncofetal antigen 5T4 conjugated to the auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of anti-5T4/MMAE ADC XB010, the anti-5T4 antibody moiety selectively binds to tumor cells expressing 5T4. Upon binding and internalization, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types while its expression is limited in normal adult tissues; its expression is correlated with increased invasiveness.",
  "synonyms": [
    "anti-5T4 ADC XB010",
    "anti-5T4 antibody-drug conjugate XB010",
    "anti-5T4/MMAE ADC XB010"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-5t4-mmae-antibody-drug-conjugate-xb010/"
}