anti-5T4/exatecan antibody-drug conjugate TUB-030

{
  "id": "MLC-T-ONC-010109",
  "term": "anti-5T4/exatecan antibody-drug conjugate TUB-030",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a Fc-silenced, humanized, immunoglobulin G1 (IgG1) monoclonal antibody directed against the oncofetal antigen 5T4 and site-specifically conjugated, via a cleavable linker, to the cytotoxic agent and DNA topoisomerase I inhibitor exatecan, with potential antineoplastic activity. Upon administration of anti-5T4/exatecan ADC TUB-030, the anti-5T4 antibody moiety selectively targets and binds to cells expressing 5T4. After internalization and cleavage within the tumor cell, exatecan is released and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in DNA damage, cell cycle arrest and apoptosis in tumor cells overexpressing 5T4. In addition, TUB-030 induces a bystander effect, thereby killing neighboring tumor cells that don't necessarily express 5T4 in the tumor environment (TME). 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types while its expression is limited in normal adult tissues; its expression is correlated with increased invasiveness.",
  "synonyms": [
    "anti-5T4 ADC TUB-030",
    "anti-5T4 antibody-drug conjugate TUB-030",
    "anti-5T4/exatecan ADC TUB-030"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-5t4-exatecan-antibody-drug-conjugate-tub-030/"
}