anti-5T4 CAR-NK cells

{
  "id": "MLC-T-ONC-010107",
  "term": "anti-5T4 CAR-NK cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic natural killer cells (NKs) expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) oncofetal trophoblast glycoprotein (5T4; TPBG; Wnt-activated inhibitory factor 1 or WAIF1), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-5T4 CAR-NK cells recognize, bind to and induce selective cytotoxicity in 5T4-expressing tumor cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness.",
  "synonyms": [
    "anti-5T4 CAR natural killer cells",
    "anti-5T4 CAR-NKs",
    "anti-5T4 CAR-redirected natural killer cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-5t4-car-nk-cells/"
}