anti-CD19/CD3 bispecific antibody TNB-486

{
  "id": "MLC-T-ONC-010278",
  "term": "anti-CD19/CD3 bispecific antibody TNB-486",
  "field": "Oncology and biomedicine",
  "definition": "A human bispecific T-cell engager antibody composed of a fixed-light-chain (FLC) arm targeting the CD3 antigen found on T lymphocytes and a heavy-chain-only (HCO) arm targeting the B-cell-specific membrane protein CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD3 bispecific antibody TNB-486 binds to both the CD3 antigen on cytotoxic T lymphocytes (CTLs) and the CD19 antigen expressed on malignant B cells. This activates and redirects CTLs to CD19-expressing tumor cells, resulting in CTL-mediated killing of tumor cells. CD19 is a membrane antigen that is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages. The FLC arm weakly activates CD3. The HCO arm has a high affinity anti-CD19 moiety.",
  "synonyms": [
    "bispecific antibody TNB-486",
    "CD19 x CD3 T-BsAb TNB-486",
    "anti-CD19/CD3 T-cell engaging bispecific antibody TNB-486"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-cd3-bispecific-antibody-tnb-486/"
}