anti-CD19/CD28 bispecific antibody RO7443904

{
  "id": "MLC-T-ONC-010274",
  "term": "anti-CD19/CD28 bispecific antibody RO7443904",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against both the tumor-associated antigen (TAA) CD19 and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD28 bispecific antibody RO7443904 targets and binds to both CD28 expressed on T cells and CD19 expressed on tumor cells, which crosslinks the T cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "anti-CD28/anti-CD19 bispecific antibody RO7443904",
    "CD19 x CD28 bispecific antibody RO7443904",
    "anti-CD19/anti-CD28 bispecific antibody RO7443904"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-cd28-bispecific-antibody-ro7443904/"
}