anti-CD19/anti-CD3/anti-CD28 trispecific antibody CC312

{
  "id": "MLC-T-ONC-010261",
  "term": "anti-CD19/anti-CD3/anti-CD28 trispecific antibody CC312",
  "field": "Oncology and biomedicine",
  "definition": "A trispecific T-cell engager and antibody targeting the tumor-associated antigen (TAA) CD19, the T-cell surface antigen CD3, and the T-cell specific surface glycoprotein and co-stimulatory molecule CD28, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/anti-CD3/anti-CD28 trispecific antibody CC312 targets and binds to CD3 and CD28 on T cells and CD19 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "CD19×CD3×CD28 trispecific antibody CC312",
    "anti-CD19/CD3/CD28 trispecific antibody CC312",
    "tri-specific T-cell engager CC312",
    "TriTE CC312"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-anti-cd3-anti-cd28-trispecific-antibody-cc312/"
}