anti-PSMA/anti-CD70 4SCAR-expressing bispecific T cells

{
  "id": "MLC-T-ONC-011055",
  "term": "anti-PSMA/anti-CD70 4SCAR-expressing bispecific T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) prostate-specific membrane antigen (PSMA) and CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-PSMA/anti-CD70 4SCAR-expressing bispecific T cells are directed to and induce selective toxicity in PSMA- and CD70-expressing tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, neuroblastoma and some lymphoma tumor tissues. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance.",
  "synonyms": [
    "bi-4SCAR PSMA/CD70 T cells",
    "anti-PSMA/CD70 bispecific 4SCAR-expressing T cells",
    "PSMA/CD70 bispecific 4SCAR-T cells",
    "anti-CD70/anti-PSMA 4SCAR-expressing bispecific T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-psma-anti-cd70-4scar-expressing-bispecific-t-cells/"
}