Autologous anti-GD2/anti-PSMA 4SCAR-expressing bispecific T cells

{
  "id": "MLC-T-ONC-011433",
  "term": "Autologous anti-GD2/anti-PSMA 4SCAR-expressing bispecific T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) disialoganglioside (GD2) and prostate-specific membrane antigen (PSMA), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-GD2/anti-PSMA 4SCAR-expressing bispecific T cells are directed to and induce selective toxicity in GD2- and PSMA-expressing tumor cells. GD2 is overexpressed on the surface of neuroblastoma (NB) cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors, including brain tumor, NB and some lymphoma tumor tissues.",
  "synonyms": [
    "autologous anti-PSMA/anti-GD2 4SCAR-expressing bispecific T cells",
    "autologous bi-4SCAR GD2/PSMA T cells",
    "autologous anti-GD2/PSMA bispecific 4SCAR-expressing T cells",
    "autologous anti-GD2/PSMA bispecific 4SCAR T cells",
    "autologous GD2/PSMA bispecific 4SCAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-gd2-anti-psma-4scar-expressing-bispecific-t-cells/"
}