autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T lymphocytes

{
  "id": "MLC-T-ONC-011432",
  "term": "autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous human T lymphocytes genetically modified to express a chimeric endocrine receptor (CER) targeting the human follicle stimulating hormone receptor (FSHR) and coupled to the signaling domains of 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T lymphocytes target and bind to the FSHR on FSHR-expressing tumor cell surfaces, thereby killing FSHR-expressing tumor cells. FSHR is not normally expressed in healthy non-ovarian tissue, but is present on several types of ovarian, fallopian tube, or primary peritoneal cancers.",
  "synonyms": [
    "autologous anti-FSHR chimeric endocrine receptor-expressing T cells",
    "autologous follicle stimulating hormone receptor-targeting chimeric endocrine receptor T cells",
    "autologous FSHCER T cells",
    "autologous FSHR-specific 4-1BB/CD3zeta CER T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-fshr-cer-4-1bb-cd3zeta-expressing-t-lymphocytes/"
}