autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells

{
  "id": "MLC-T-ONC-011361",
  "term": "autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that are engineered to express a chimeric antigen receptor (CAR) composed of an anti-cluster of differentiation 19 (CD19) single chain variable fragment (scFv) linked to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous anti-CD19 CAR-CD3zeta-4-1BB-expressing T cells, these cells target, bind to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "autologous CD3zeta-4-1BB-expressing CART-19 cells",
    "autologous CD19CAR-CD3zeta-4-1BB-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd19-car-cd3zeta-4-1bb-expressing-t-cells/"
}