anti-GD2/anti-CD70 4SCAR-expressing bispecific T cells

{
  "id": "MLC-T-ONC-010691",
  "term": "anti-GD2/anti-CD70 4SCAR-expressing bispecific T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that are genetically engineered to express a fourth-generation chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs) disialoganglioside (GD2) and CD70 (CD27 ligand; tumor necrosis factor superfamily member 7; TNFSF7), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-GD2/anti-CD70 4SCAR-expressing bispecific T cells are directed to and induce selective toxicity in GD2- and CD70-expressing tumor cells. GD2 is overexpressed on the surface of neuroblastoma cells and by other neuroectoderm-derived neoplasms, while it is minimally expressed on normal cells. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF) and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of various types of cancer cells; its overexpression may play an important role in the evasion of immune surveillance.",
  "synonyms": [
    "anti-CD70/anti-GD2 4SCAR-expressing bispecific T cells",
    "anti-GD2/CD70 bispecific 4SCAR-expressing T cells",
    "bi-4SCAR GD2/CD70 T cells",
    "GD2/CD70 bispecific 4SCAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gd2-anti-cd70-4scar-expressing-bispecific-t-cells/"
}