anti-CD70 monoclonal antibody MDX-1411

{
  "id": "MLC-T-ONC-010432",
  "term": "anti-CD70 monoclonal antibody MDX-1411",
  "field": "Oncology and biomedicine",
  "definition": "A glycoengineered, fully human IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Anti-CD70 fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on renal cell carcinoma (RCC) cells among other cancer cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd70-monoclonal-antibody-mdx-1411/"
}