anti-CD70 monoclonal antibody IMM40H

{
  "id": "MLC-T-ONC-010431",
  "term": "anti-CD70 monoclonal antibody IMM40H",
  "field": "Oncology and biomedicine",
  "definition": "An immunoglobulin G1 (IgG1) monoclonal antibody directed against the human tumor-associated antigen (TAA) CD70, with potential immunomodulatory and antineoplastic activities. Upon administration, anti-CD70 monoclonal antibody IMM40H selectivity targets and binds to CD70, which blocks CD70-mediated signaling. This may inhibit cellular proliferation and survival of CD70-expressing tumor cells, and may modulate the immune system to inhibit inflammatory signals and increase antigen-specific T-cell responses in the tumor microenvironment (TME). In addition, IMM40H induces antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) against CD70-expressing tumor cells. CD70, a member of the tumor necrosis factor (TNF) family, is aberrantly expressed on malignant myeloid blasts while absent from healthy hematopoietic progenitor cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd70-monoclonal-antibody-imm40h/"
}