PSMA/CD3 tri-specific T-cell activating construct HPN424

{
  "id": "MLC-T-ONC-016280",
  "term": "PSMA/CD3 tri-specific T-cell activating construct HPN424",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant antibody derivative composed of tri-specific T-cell activating construct (TriTAC) directed against the human tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA; FOLH1) and the CD3 antigen found on T lymphocytes and an albumin-binding domain, with potential immunostimulating and antineoplastic activities. Upon administration, PSMA/CD3 tri-specific T-cell antibody construct HPN424 targets and binds PSMA on tumor cells and CD3 on cytotoxic T lymphocytes (CTLs), thereby bringing PSMA-expressing tumor cells and CTLs together, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. The albumin-binding domain targets and binds to serum albumin, thereby extending the serum half-life of HPN424. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate tumor cells.",
  "synonyms": [
    "TriTAC HPN424",
    "anti-PSMA/CD3 TriTAC HPN424",
    "PSMA/CD3-specific TriTAC HPN424",
    "PSMA/CD3 TriTAC HPN424"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/psma-cd3-tri-specific-t-cell-activating-construct-hpn424/"
}