mesothelin/CD3e tri-specific T-cell activating construct HPN536

{
  "id": "MLC-T-ONC-015105",
  "term": "mesothelin/CD3e tri-specific T-cell activating construct HPN536",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant antibody derivative composed of a tri-specific T-cell activating construct (TriTAC) directed against the human tumor-associated antigen (TAA) mesothelin (MSLN) and the epsilon domain of CD3 antigen (CD3e) found on T lymphocytes which are both linked to either side of an anti-albumin single domain antibody, with potential immunostimulating and antineoplastic activities. Upon administration of the MSLN/CD3e TriTAC HPN536, the anti-MSLN single antibody domain targets and binds MSLN on tumor cells and the anti-CD3e single-chain variable fragment (scFv) targets and binds to CD3e on cytotoxic T lymphocytes (CTLs), thereby bringing MSLN-expressing tumor cells and CTLs together, which results in the CTL-mediated cell death of MSLN-expressing tumor cells. The albumin-binding domain targets and binds to serum albumin, thereby extending the serum half-life of HPN536. MSLN is overexpressed on the surface of certain tumor cell types. Overexpression of MSLN is often associated with poor prognosis.",
  "synonyms": [
    "TriTAC HPN536",
    "mesothelin/CD3e-specific TriTAC HPN536",
    "mesothelin-targeting T-cell engager HPN536",
    "MSLN/CD3e TriTAC HPN536"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mesothelin-cd3e-tri-specific-t-cell-activating-construct-hpn536/"
}