autologous anti-mesothelin CAR-T cells UCLM802

{
  "id": "MLC-T-ONC-011473",
  "term": "autologous anti-mesothelin CAR-T cells UCLM802",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-MSLN CAR-T cells UCLM802 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "autologous anti-MSLN CAR-T cells UCLM802"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-mesothelin-car-t-cells-uclm802/"
}