autologous anti-mesothelin TNhYP218 CAR T cells

{
  "id": "MLC-T-ONC-011478",
  "term": "autologous anti-mesothelin TNhYP218 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes containing primarily naive and stem cell-like memory (scm) T cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the membrane-proximal region of the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-MSLN TNhYP218 CAR T cells specifically target the membrane-proximal region of MSLN and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types. Targeting the membrane-proximal region of MSLN may increase the killing of tumor cells and improve T-cell persistence. Naive and scm T cells may exhibit increased persistence and decreased exhaustion.",
  "synonyms": [
    "autologous anti-mesothelin TNaive/SCM hYP218 CAR T cells",
    "autologous anti-MSLN hYP218 CAR naive and stem cell-like memory T cells",
    "autologous anti-MSLN TNhYP218 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-mesothelin-tnhyp218-car-t-cells/"
}