anti-MSLN/anti-CD3 bispecific antibody ZW171

{
  "id": "MLC-T-ONC-010900",
  "term": "anti-MSLN/anti-CD3 bispecific antibody ZW171",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific T-cell engager (TCE) and bispecific antibody directed against both the tumor-associated antigen (TAA) mesothelin (MSLN) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-MSLN/anti-CD3 bispecific antibody ZW171 bivalently binds to MSLN expressed on tumor cells and monovalently binds to CD3 expressed on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to MSLN-expressing tumor cells, which results in the CTL-mediated death of MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "anti-mesothelin/anti-CD3 bispecific antibody ZW171",
    "anti-MSLN/CD3 T-cell engaging bispecific antibody ZW171",
    "MSLN x CD3 2 +1 bispecific antibody ZW171",
    "MSLN-targeting T-cell engager ZW171",
    "TCE ZW171"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-msln-anti-cd3-bispecific-antibody-zw171/"
}