Mesothelin-specific chimeric antigen receptor-engineered peripheral blood lymphocytes

{
  "id": "MLC-T-ONC-015106",
  "term": "Mesothelin-specific chimeric antigen receptor-engineered peripheral blood lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers.",
  "abbreviation": "mesothelin-specific CAR-engineered PBLs",
  "synonyms": [
    "anti-mesothelin CAR PBL"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mesothelin-specific-chimeric-antigen-receptor-engineered-peripheral-blood/"
}