autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11

{
  "id": "MLC-T-ONC-011698",
  "term": "autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11",
  "field": "Oncology and biomedicine",
  "definition": "Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers.",
  "synonyms": [
    "anti-mesothelin mRNA-transfected autologous PBMCs MCY-M11"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mesothelin-specific-human-mrna-car-transfected-pbmcs-mcy-m11/"
}