autologous mesothelin-specific CAR-T cells expressing anti-PD-1/CTLA-4 antibodies

{
  "id": "MLC-T-ONC-011697",
  "term": "autologous mesothelin-specific CAR-T cells expressing anti-PD-1/CTLA-4 antibodies",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, engineered T lymphocytes that express both a second-generation chimeric antigen receptor (CAR) specific for the human gastric carcinoma-associated antigen MG7, and the co-stimulatory molecule 4-1BB (CD137), with potential antineoplastic activity. Upon intratumoral injection, the autologous anti-MG7-CAR T lymphocytes target and attach to cancer cells expressing MG7. This induces selective toxicity in and causes lysis of MG7-expressing tumor cells. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types. 4-1BB enhances T-cell activation and signaling after recognition of MG7.",
  "synonyms": [
    "autologous anti-CTLA-4/PD-1 antibodies-expressing mesothelin-targeted CAR-T cells",
    "autologous CTLA4/PD-1-targeting antibodies-expressing mesothelin-CAR-T cells",
    "autologous CTLA-4 and PD-1 antibodies expressing mesothelin-CAR-T cells",
    "autologous anti-CTLA-4/PD-1 antibodies-expressing meso-CAR-T cells",
    "autologous anti-MG7 CAR-T cells",
    "autologous anti-MG7-CAR T lymphocytes",
    "autologous MG7-CART",
    "autologous MG7-CART cells",
    "MG7-targeted chimeric antigen receptor T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mesothelin-specific-car-t-cells-expressing-anti-pd-1-ctla-4/"
}