autologous tumor-infiltrating lymphocytes-central memory T cells

{
  "id": "MLC-T-ONC-011808",
  "term": "autologous tumor-infiltrating lymphocytes-central memory T cells",
  "field": "Oncology and biomedicine",
  "definition": "An agent that targets the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and redirects T-cells to PSMA-expressing tumor cells, with potential antineoplastic activity. Although the mechanism of action has not been elucidated, upon administration, PSMA-targeting T-cell redirecting agent JNJ-80038114 targets PSMA found on PSMA-expressing tumor cells, and redirects T cells to the PSMA-expressing tumor cells. This may result in T-cell-mediated cell death of PSMA-expressing tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.",
  "synonyms": [
    "TIL-TCM cells",
    "autologous TIL-TCM cells",
    "autologous TIL-TCMs",
    "autologous tumor-infiltrating lymphocytes-memory T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tumor-infiltrating-lymphocytes-central-memory-t-cells/"
}