fluorine F 18 PSMA-1007

{
  "id": "MLC-T-ONC-013694",
  "term": "fluorine F 18 PSMA-1007",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate containing the human prostate-specific membrane antigen (PSMA)-targeting ligand, PSMA-1007, labeled with the radioisotope fluorine F 18, with potential imaging activity using positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 PSMA-1007, the PSMA-1007 moiety targets and binds to PSMA-expressing tumor cells. This allows for visualization of PSMA-expressing cells upon imaging. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and strongly overexpressed in prostate cancer (PCa) cells, with its level rising with increasing tumor differentiation and in hormone-refractory cancers.",
  "abbreviation": "F-18-PSMA-1007",
  "synonyms": [
    "[18F]-PSMA-1007",
    "fluorine-18 PSMA-1007",
    "18FPSMA-1007",
    "PSMA-1007 F-18"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-psma-1007/"
}