PSMA-targeted PET imaging agent fluorine F 18 CTT-1057

{
  "id": "MLC-T-ONC-016283",
  "term": "PSMA-targeted PET imaging agent fluorine F 18 CTT-1057",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the phosphoramidate agent CTT1057, a human prostate specific membrane antigen (PSMA) inhibitor, and labeled with the radioisotope fluorine F 18, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of PSMA-targeted PET imaging agent fluorine F 18 CTT-1057, the CTT-1057 moiety targets and irreversibly binds to the extracellular domain of PSMA-expressing tumor cells. Upon rapid internalization, and following PET imaging, PSMA-expressing tumor cells can be detected. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.",
  "synonyms": [
    "CTT 1057 18F",
    "CTT 1057 F18",
    "fluorine-18-CTT 1057",
    "fluorine F 18 CTT1057",
    "18F-CTT-1057"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/psma-targeted-pet-imaging-agent-fluorine-f-18-ctt-1057/"
}