fluorine F 18 PT2385

{
  "id": "MLC-T-ONC-013695",
  "term": "fluorine F 18 PT2385",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate containing PT2385, a small molecule inhibitor of the hypoxia inducible factor (HIF)-2alpha, conjugated to the positron-emitting isotope fluorine F 18, with potential imaging activity upon positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 PT2385, the PT2385 moiety specifically targets and binds to HIF-2alpha overexpressed on tumor cells, thereby allowing the visualization of tumor cells expressing HIF-2alpha upon PET/CT. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.",
  "synonyms": [
    "18F-PT2385",
    "[18F]-PT2385",
    "[18F]PT2385",
    "fluorine-18 PT2385"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-pt2385/"
}