HIF-2alpha inhibitor HS-10516

{
  "id": "MLC-T-ONC-014122",
  "term": "HIF-2alpha inhibitor HS-10516",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor HS-10516 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.",
  "synonyms": [
    "HIF-2-alpha inhibitor HS-10516",
    "HIF2-alpha inhibitor HS-10516",
    "HIF2a inhibitor HS-10516",
    "HIF2alpha inhibitor HS-10516"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hif-2alpha-inhibitor-hs-10516/"
}