HIF2-alpha inhibitor NKT2152

{
  "id": "MLC-T-ONC-014123",
  "term": "HIF2-alpha inhibitor NKT2152",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor NKT2152 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.",
  "synonyms": [
    "HIF2a inhibitor NKT2152",
    "HIF-2alpha inhibitor NKT2152"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/hif2-alpha-inhibitor-nkt2152/"
}