autologous UV-oHSV2-activated peripheral blood mononuclear cells

{
  "id": "MLC-T-ONC-011812",
  "term": "autologous UV-oHSV2-activated peripheral blood mononuclear cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous peripheral blood mononuclear cells (PBMCs) activated ex vivo by ultraviolet-inactivated oncolytic herpes simplex virus type 2 (UV-oHSV2), with potential immunomodulating and antineoplastic activities. Upon reintroduction of the autologous UV-oHSV2-activated PBMCs into the patient, the activated immune cells kill tumor cells. Ex vivo UV-oHSV2 treatment induces natural killer (NK) cell proliferation and the secretion of interferon-gamma (IFNg). This leads to immune-mediated tumor cell death and the inhibition of tumor cell proliferation.",
  "synonyms": [
    "autologous VAK immune cells",
    "autologous UV-oHSV2-activated PBMCs",
    "autologous ultraviolet inactivated oncolytic herpes simplex virus type 2-activated peripheral blood mononuclear cells",
    "autologous virus-activated killer immune cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-uv-ohsv2-activated-peripheral-blood-mononuclear-cells/"
}