Autologous tumor killer cells

{
  "id": "MLC-T-ONC-011798",
  "term": "Autologous tumor killer cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor killer cells (TKCs) which consists of the innate immune cells natural killer (NK) cells and gamma delta T (gdT) cells, which are T lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential cytolytic and antineoplastic activities. NK cells and gdT cells are isolated from the patients' peripheral blood mononuclear cells (PBMCs) and co-cultured ex vivo in a certain proportion with TKC technology. Upon administration, autologous TKCs may lyse cancer cells, and further stimulate an anti-tumor immune response.",
  "synonyms": [
    "co-cultured autologous NK cells and gdT cells",
    "autologous TKCs",
    "autologous NK cells/gamma-delta-T cells",
    "autologous NK/gd-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-tumor-killer-cells/"
}