allogeneic CS1-specific universal CAR-expressing T lymphocytes UCARTCS1A

{
  "id": "MLC-T-ONC-009873",
  "term": "allogeneic CS1-specific universal CAR-expressing T lymphocytes UCARTCS1A",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC), with potential immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CS1-specific universal CAR-expressing T lymphocytes UCARTCS1A, these cells target and bind to cancer cells expressing CS1. This induces selective toxicity in and causes lysis of CS1-expressing tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells.",
  "synonyms": [
    "allogenic engineered T cells expressing anti- CS1 CAR UCARTCS1A",
    "allogeneic gene-edited CAR T cells UCARTCS1A",
    "allogeneic TALEN gene-edited CAR T cells UCARTCS1A",
    "UCARTCS1A cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-cs1-specific-universal-car-expressing-t-lymphocytes-ucartcs1a/"
}