autologous anti-SLAMF7 CAR-expressing T cells

{
  "id": "MLC-T-ONC-011501",
  "term": "autologous anti-SLAMF7 CAR-expressing T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) recognizing human SLAM family member 7 (SLAMF7; CD319 CRACC; CS-1) with potential antineoplastic activity. Upon intravenous administration, the autologous anti-SLAMF7 CAR-expressing T cells target and induce selective toxicity in SLAMF7-expressing tumor cells. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells.",
  "synonyms": [
    "autologous anti-SLAMF7 CAR T cells",
    "anti-CS1 CAR-expressing T cells",
    "anti-SLAMF7 CAR-expressing T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-slamf7-car-expressing-t-cells/"
}