autologous anti-CS1 hinge-optimized CAR-4-1BB-EGFRt-expressing memory-enriched T cells

{
  "id": "MLC-T-ONC-011419",
  "term": "autologous anti-CS1 hinge-optimized CAR-4-1BB-EGFRt-expressing memory-enriched T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous central memory-enriched T cells (Tcm) that have been transduced with a self-inactivating (SIN) lentiviral vector expressing a hinge-optimized chimeric antigen receptor (CAR) comprised of a CS1 (CD2 subset 1; SLAM family member 7; SLAMF7; CD319; CRACC)-specific single chain variable fragment (scFV), fused to the costimulatory signaling domain of 4-1BB (CD137), and a truncated human epidermal growth factor receptor (huEGFRt), with potential antineoplastic activity. Upon intravenous infusion, anti-CS1-CAR-4-1BB-CD3z-EGFRt-expressing Tcm-enriched T lymphocytes target and induce selective toxicity in CS-1-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed huEGFRt facilitates both in vivo detection of the administered, transduced T cells and can promote elimination of those cells through a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. CS1, a cell surface glycoprotein of the signaling lymphocyte activation molecule (SLAM) receptor family, is highly expressed on certain malignant plasma cells.",
  "synonyms": [
    "CS1 CAR-T cells",
    "autologous anti-CS1 hinge-optimized CAR-4-1BB-EGFRt-expressing memory-enriched T lymphocytes",
    "anti-CS1 hinge-optimized CAR-4-1BB-EGFRt-expressing memory-enriched autologous T lymphocytes",
    "CS1-CAR T lymphocytes",
    "anti-CS1 hinge-optimized CAR-4-1BB-EGFRt-expressing memory-enriched autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cs1-hinge-optimized-car-4-1bb-egfrt-expressing-memory-enriched-t/"
}