anti-CD19-CAR CMV-specific T lymphocytes

{
  "id": "MLC-T-ONC-010264",
  "term": "anti-CD19-CAR CMV-specific T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of human cytomegalovirus (CMV)-specific T lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) specific for the human tumor associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR CMV-specific T lymphocytes recognize, bind to, and induce selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. The anti-CD19-CAR CMV-specific T lymphocytes may potentially be expanded in vivo through CMV vaccination.",
  "synonyms": [
    "anti-CD19-CAR CMV-specific T cells",
    "CMV-specific CD19 CAR T Cells",
    "CMV-specific CD19-CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-car-cmv-specific-t-lymphocytes/"
}