autologous T-lymphocytes-expressing NY-ESO-1-C259-specific enhanced T-cell receptors

{
  "id": "MLC-T-ONC-011777",
  "term": "autologous T-lymphocytes-expressing NY-ESO-1-C259-specific enhanced T-cell receptors",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous T-lymphocytes expressing NY-ESO-1-C259-specific enhanced T cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide, in a complex with human leukocyte antigen (HLA) A2 peptide.",
  "synonyms": [
    "NY-ESO-1/C259T",
    "NY-ESO-1C259T",
    "NY-ESOc259T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-t-lymphocytes-expressing-ny-eso-1-c259-specific-enhanced-t-cell/"
}