allogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR

{
  "id": "MLC-T-ONC-009945",
  "term": "allogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR",
  "field": "Oncology and biomedicine",
  "definition": "Genetically engineered human allogeneic T lymphocytes that are transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and introduction into the patient, the allogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR specifically target and bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is expressed in normal testis and on the surface of various tumor cell types.",
  "synonyms": [
    "NY-ESO-1 c259 T cells",
    "allogeneic NY-ESO-1-c259 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-t-lymphocytes-expressing-ny-eso-1-c259-specific-tcr/"
}