letetresgene autoleucel

{
  "id": "MLC-T-ONC-014753",
  "term": "letetresgene autoleucel",
  "field": "Oncology and biomedicine",
  "definition": "Human autologous T lymphocytes transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for the cancer-testis antigens (CTAs) NY-ESO-1 and L antigen family member 1 (LAGE-1; Cancer/Testis Antigen 2; CTAG2; CT2), with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and reintroduction into the patient, letetresgene autoleucel specifically target and bind to NY-ESO-1/LAGE-1-overexpressing tumor cells. This may result in a cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1/LAGE-1-positive cancer cells. NY-ESO-1 and LAGE-1, members of the cancer-testis antigen (CTA) family, are overexpressed on the surface of various tumor cell types.",
  "synonyms": [
    "genetically engineered NY-ESO-1/LAGE-1 specific (c259) T cells GSK3377794",
    "autologous anti-NY-ESO-1/LAGE-1 TCR-transduced c259 T lymphocytes GSK3377794",
    "autologous T-cells expressing enhanced TCRs specific for NY-ESO-1/LAGE-1a GSK3377794",
    "genetically engineered NY-ESO-1 specific [c259] T cells GSK3377794",
    "NY-ESO-1c259 T cells GSK3377794"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/letetresgene-autoleucel/"
}