NY-ESO-1-specific TCR gene-transduced T lymphocytes TBI-1301

{
  "id": "MLC-T-ONC-015575",
  "term": "NY-ESO-1-specific TCR gene-transduced T lymphocytes TBI-1301",
  "field": "Oncology and biomedicine",
  "definition": "Human peripheral blood T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and introduction into the patient, the NY-ESO-1-specific TCR gene-transduced T lymphocytes TBI-1301 bind to NY-ESO-1 on tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated elimination of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types.",
  "synonyms": [
    "NY-ESO-1-specific TCR gene-transduced T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ny-eso-1-specific-tcr-gene-transduced-t-lymphocytes-tbi-1301/"
}