autologous CD19 CAR-expressing CD4+/CD8+ T cells MB-CART19.1

{
  "id": "MLC-T-ONC-011536",
  "term": "autologous CD19 CAR-expressing CD4+/CD8+ T cells MB-CART19.1",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of CD4+ and CD8+ autologous T lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4+/CD8+ T cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "autologous CD19 CAR-transduced CD4/CD8 enriched T cells MB-CART19.1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd19-car-expressing-cd4-plus-cd8-plus-t-cells-mb-cart19-1/"
}