alloantigen-specific allogeneic type 1 regulatory T cells T-allo10

{
  "id": "MLC-T-ONC-009786",
  "term": "alloantigen-specific allogeneic type 1 regulatory T cells T-allo10",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic CD4+ cells that were ex vivo stimulated with alloantigens, which involves exposing the cells to host antigen-presenting cells (APCs), in the presence of the immunomodulatory cytokine interleukin-10 (IL-10), with potential to prevent graft-versus-host disease (GvHD). The stimulation of the CD4+ cells by exposure to alloantigens plus IL-10 induces the differentiation of alloantigen-specific type 1 T regulatory (TR1) cells, which are hyporesponsive to the alloantigens. Upon infusion of T-allo10 and prior to donor hematopoietic stem cell transplantation (HSCT), the alloantigen-specific type 1 regulatory T cells are tolerant to the alloantigens and suppress alloreactive immune responses by donor CD4+ and CD8+ T cells. This may ultimately prevent GvHD. IL-10 plays a key role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. IL-10 induces both a long lasting antigen specific T-cell anergy and the differentiation of TR1 cells.",
  "abbreviation": "T-allo10",
  "synonyms": [
    "alloantigen-specific type 1 Tregs T-allo10",
    "T-allo10 cells",
    "alloantigen-specific TR1 cells Allo10",
    "donor-derived host alloantigen-specific IL-10 anergized T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alloantigen-specific-allogeneic-type-1-regulatory-t-cells-t-allo10/"
}