autologous HER2-CAR-modified adenovirus-specific cytotoxic T lymphocytes

{
  "id": "MLC-T-ONC-011644",
  "term": "autologous HER2-CAR-modified adenovirus-specific cytotoxic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A population of autologous cytotoxic T lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) that have been transduced with a retroviral vector expressing a second-generation human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific chimeric antigen receptor (CAR) comprised of an exodomain based on a anti-CD22 single chain variable fragment (scFv) from the anti-HER2 monoclonal antibody FRP5 that is linked to the costimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous HER2-CAR-modified Ad-specific CTLs are directed to and induce selective toxicity in HER2-expressing tumor cells. Additionally, these cells may help reconstitute Ad-specific CTL responses in immunocompromised individuals and others at risk of developing Ad-infection. HER2, a receptor tyrosine kinase (RTK) overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and plays a key role in tumor cell proliferation.",
  "synonyms": [
    "HER2.CAR.AdVST",
    "HER2-AdVST",
    "HER2-CAR-modified Ad-specific CTLs",
    "HER2-CAR-modified autologous AdVSTs",
    "HER2-CAR-modified adenovirus-specific CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-her2-car-modified-adenovirus-specific-cytotoxic-t-lymphocytes/"
}