autologous anti-HER2 CAR monocytes CT-0525

{
  "id": "MLC-T-ONC-011449",
  "term": "autologous anti-HER2 CAR monocytes CT-0525",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous monocytes genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR monocytes CT-0525 specifically recognize and bind to HER2-expressing tumor cells, and expose the immune system to the HER2 antigen. This may elicit a cytotoxic T-lymphocyte (CTL) response against HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.",
  "synonyms": [
    "autologous anti-HER2 CAR-mono CT-0525",
    "autologous anti-HER2 CAR-monocytes CT-0525"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-her2-car-monocytes-ct-0525/"
}