autologous anti-HER2 CAR-CD28 T cells

{
  "id": "MLC-T-ONC-011452",
  "term": "autologous anti-HER2 CAR-CD28 T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2) and coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-HER2 CAR-CD28 T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.",
  "synonyms": [
    "Autologous Anti-HER2 CAR-CD28 T-cells",
    "autologous anti-HER2 CAR-CD28-expressing T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-her2-car-cd28-t-cells/"
}